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Li-mei Yu, [email protected] These authors have contributed equally to this work This article was submitted to Multiple Sclerosis and Neuroimmunology, a section of the journal Frontiers in Immunology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Benjamin EJ, Blaha MJ, Chiuve SE, Cushman M, Das SR et al (2017) American Heart Association Statistics Committee and Stroke Statistics Subcommittee Heart Disease and Stroke Statistics-2017 update: a report from the American